Sequence and structure of CYP46A1

CYP46A1 is a member of the cytochrome P450 (CYP) superfamily of enzymes that catalyzes the conversion of cholesterol to 24S-hydroxycholesterol. This page shows the sequence, secondary structure and three-dimensional structure of that protein based on 2Q9F​ PDB deposit.

This page demonstrates actually four widgets, that are available from VisuaLife library:

  • SequenceViewer displays an amino acid sequence and its annotations, such as heame and cholesterol binding sites as well as a region for allosteric regulation by efavirenz
  • SecondaryStructure viewer shows the secondary structure of that protein (as defined in the PDB file header)
  • GLViewerWidget displays the 3D structure of that protein
  • AjaxSender widget - not visible on the page - is used for client-server communication

Allosteric regulation region according to: K Anderson et al. Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity J Biol Chem 2016 May 27:11876-86. doi: 10.1074/jbc.M116.723577

CYP46A1 sequence annotations